Optimal probe geometry for near-infrared spectroscopy of biological tissue

被引:84
作者
Kumar, G
Schmitt, JM
机构
[1] Electrical and Electronic Engineering Department, Hong Kong University of Science and Technology, Kowloon, Clear Water Bay
来源
APPLIED OPTICS | 1997年 / 36卷 / 10期
关键词
near-infrared spectroscopy; multiple scattering; turbid materials; photon diffusion;
D O I
10.1364/AO.36.002286
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
The results of this study clarify the influence of probe geometry on spectroscopic measurements obtained from the surface of a turbid biological tissue. We show that the transition between the measurement of the predominantly backward-propagating and the predominantly forward-propagating photon fluxes is marked by the separation between the source probe and the detector probes at which the dependence of the fluence on small changes in scattering coefficient vanishes. This is the probe separation at which a variable scattering background has the least influence on the measurement of optical absorption in turbid materials. Estimates of the optimum probe spacing for typical values of absorption and scattering coefficients of soft tissue in the near-infrared spectral region (800-2500 nm) are derived from an analytical solution of the diffusion equation. The estimates were verified by Monte Carlo simulations and experiments on particle suspensions with optical properties similar to those of skin tissue. (C) 1997 Optical Society of America.
引用
收藏
页码:2286 / 2293
页数:8
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