The physiological regulation of uncoupling proteins

被引：147

作者：

Nicholls, David G. ^{[1
]}

机构：

[1] Mitochondrial Physiol, Buck Inst Age Res, Novato, CA 94945 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2006年 / 1757卷 / 5-6期

关键词：

uncoupling protein; mitochondria; purine nucleotide; fatty acid; thermogenesis; membrane potential; proton conductance;

D O I：

10.1016/j.bbabio.2006.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite the enormous interest in the roles of novel uncoupling proteins, there is still great uncertainty as to their mechanism and regulation. The regulation of the architypal uncoupling protein 1 from brown adipose tissue was elucidated more than 20 years ago. This review suggests that a number of the approaches and criteria developed for the study of UCP1 could with profit be applied to current investigations of the novel UCPs. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：459 / 466

页数：8

共 53 条

[1] Mitochondrial uncoupling proteins in the CNS: In support of function and survival [J].

Andrews, ZB ;

Diano, S ;

Horvath, TL .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (11) :829-840

[2] Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4 [J].

Bouillaud, F ;

Couplan, E ;

Pecqueur, C ;

Ricquier, D .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2001, 1504 (01) :107-119

[3] The efficiency and plasticity of mitochondrial energy transduction [J].

Brand, MD .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 :897-904

[4] Mitochondrial superoxide: Production, biological effects, and activation of uncoupling proteins [J].

Brand, MD ;

Affourtit, C ;

Esteves, TC ;

Green, K ;

Lambert, AJ ;

Miwa, S ;

Pakay, JL ;

Parker, N .

FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (06) :755-767

[5] Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3 [J].

Brand, MD ;

Esteves, TC .

CELL METABOLISM, 2005, 2 (02) :85-93

[6] The significance and mechanism of mitochondrial proton conductance [J].

Brand, MD ;

Brindle, KM ;

Buckingham, JA ;

Harper, JA ;

Rolfe, DFS ;

Stuart, JA .

INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (Suppl 6) :S4-S11

[7] Body mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea [J].

Chang, SA ;

Kim, HS ;

Yoon, KH ;

Ko, SH ;

Kwon, HS ;

Kim, SR ;

Lee, WC ;

Yoo, SJ ;

Son, HS ;

Cha, BY ;

Lee, KW ;

Son, HY ;

Kang, SK .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2004, 53 (02) :142-146

[8] Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity [J].

Conti, B ;

Sugama, S ;

Lucero, J ;

Winsky-Sommerer, R ;

Wirz, SA ;

Maher, P ;

Andrews, Z ;

Barr, AM ;

Morale, MC ;

Paneda, C ;

Pemberton, J ;

Gaidarova, S ;

Behrens, MM ;

Beal, F ;

Sanna, PP ;

Horvath, TL ;

Bartfai, T .

JOURNAL OF NEUROCHEMISTRY, 2005, 93 (02) :493-501

[9] Mitochondrial uncoupling proteins: New perspectives for evolutionary ecologists [J].

Criscuolo, F ;

Gonzalez-Barroso, MD ;

Bouillaud, F ;

Ricquier, D ;

Miroux, B ;

Sorci, G .

AMERICAN NATURALIST, 2005, 166 (06) :686-699

[10] QUANTIFICATION OF FATTY-ACID ACTIVATION OF THE UNCOUPLING PROTEIN IN BROWN ADIPOCYTES AND MITOCHONDRIA FROM THE GUINEA-PIG [J].

CUNNINGHAM, SA ;

WIESINGER, H ;

NICHOLLS, DG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 157 (02) :415-420

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