Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder

被引:328
作者
Foley, DL
Eaves, LJ
Wormley, B
Silberg, JL
Maes, HH
Kuhn, J
Riley, B
机构
[1] Virginia Commonwealth Univ, Dept Human Genet, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA 23298 USA
[3] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA
[4] Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA 23298 USA
关键词
D O I
10.1001/archpsyc.61.7.738
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder. Objective: To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys. Design: Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline. Setting: A community-based sample of twin boys. Participants: Five hundred fourteen male twins aged 8 to 17 years. Main Outcome Measure: Conduct disorder. Results: There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction. Conclusion: This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.
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收藏
页码:738 / 744
页数:7
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