Chitosan as scaffold materials: Effects of molecular weight and degree of deacetylation

被引：106

作者：

Hsu, SH

Whu, SW

Tsai, CL

Wu, YH

Chen, HW

Hsieh, KH

机构：

[1] Natl Chung Hsing Univ, Dept Chem Engn, Taichung 402, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Orthopaed, Taipei, Taiwan

[3] Natl Chung Hsing Univ, Dept Food Sci, Taichung 402, Taiwan

[4] Natl Taiwan Univ, Dept Chem Engn, Taipei 10764, Taiwan

来源：

JOURNAL OF POLYMER RESEARCH | 2004年 / 11卷 / 02期

关键词：

biocompatibility; chitosan; degradation; degree of deacetylation; hydrophilicity; mechanical properties;

D O I：

10.1023/B:JPOL.0000031080.70010.0b

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this study, we investigated in vitro the role of the degree of deacetylation and molecular weight on some biological properties of chitosan films. The influence of different degree of deacetylation and molecular weight of chitosan on the hydrophilicity, degradation, mechanical properties and biocompatibility were evaluated. The results showed that the degree of deacetylation affected the hydrophilicity and biocompatibility of the chitosan films. The molecular weight, on the other hand. affected the rate of degradation and the mechanical properties. Chitosan with higher degree of deacetylation and molecular weight was more suitable for tissue engineering applications. Alginate could be added into chitosan to modify the rigidity and hydrophilicity of chitosan. Higher hydrophilicity, biocompatibility, and elongation were found after modification.

引用

页码：141 / 147

页数：7

共 39 条

[1] CHITOSAN AND MODIFIED CHITOSAN MEMBRANES .1. PREPARATION AND CHARACTERIZATION [J].