Biology of circulating mRNA - Still more questions than answers?

被引：20

作者：

Fleischhacker, Michael ^{[1
]}

机构：

[1] Univ Med Berlin, Med Klin Onkol Hamatol Molekularbiol Labor, D-10117 Berlin, Germany

来源：

CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM IV | 2006年 / 1075卷

关键词：

extracellular RNA; review; plasma; free-circulating RNA; cancer;

D O I：

10.1196/annals.1368.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A few years after the first description of free-circulating DNA in plasma and serum, the detection of tumor-associated overexpressed mRNA in plasma was also reported. This observation has been confirmed and it seems to be clear that the presence of free-circulating RNA is a ubiquitous phenomenon. In this short review I will discuss some basic aspects of the release mechanisms for the RNA, its biological meaning, and clinical value.

引用

页码：40 / 49

页数：10

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