Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model

被引：59

作者：

Lee, Hyun A. ^{[1
,2
]}

Leavens, Teresa L. ^{[1
]}

Mason, Sharon E. ^{[1
]}

Monteiro-Riviere, Nancy A. ^{[1
]}

Riviere, Jim E. ^{[1
,2
]}

机构：

[1] N Carolina State Univ, Coll Vet Med, Ctr Chem Toxicol Res & Pharmacokinet, Raleigh, NC 27606 USA

[2] N Carolina State Univ, Coll Phys & Math Sci, Biomath Grad Program, Raleigh, NC 27695 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 02期

关键词：

CARDIAC-OUTPUT; NANOPARTICLES; RATS; SKIN; QUANTUM-DOT-705;

D O I：

10.1021/nl803481q

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A physiologically based pharmacokinetic model with partition coefficients estimated from quantum dot (QD) 705 biodistribution was compared with the biodistribution of other QDs in mice and rats to determine the model's predictive ability across OD types, species, and exposure routes. The model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different OD biodistribution. Therefore, more complex models will be needed to better predict QD biodistribution in vivo.

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收藏

页码：794 / 799

页数：6

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