Bronchopulmonary Disposition of Micafungin in Healthy Adult Volunteers

被引：24

作者：

Nicasio, Anthony M. ^{[1
]}

Tessier, Pamela R. ^{[1
]}

Nicolau, David P. ^{[1
,2
]}

Knauft, R. Fredrick ^{[3
]}

Russomanno, John ^{[3
]}

Shore, Eric ^{[3
]}

Kuti, Joseph L. ^{[1
]}

机构：

[1] Hartford Hosp, Ctr Antiinfect Res & Dev, Hartford, CT 06102 USA

[2] Hartford Hosp, Dept Med, Div Infect Dis, Hartford, CT 06102 USA

[3] Hartford Hosp, Dept Med, Div Pulmonol, Hartford, CT 06102 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 03期

关键词：

INVASIVE PULMONARY ASPERGILLOSIS; STEADY-STATE; TRANSPLANT RECIPIENTS; ANTIFUNGAL THERAPY; DEPENDENT ACTIVITY; FUMIGATUS CONIDIA; MURINE MODEL; PHARMACOKINETICS; CASPOFUNGIN; PHARMACODYNAMICS;

D O I：

10.1128/AAC.01386-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

By way of bronchoscopy and bronchoalveolar lavage, intrapulmonary steady-state concentrations of micafungin administered at 150 mg daily to 15 healthy volunteers were determined at 4, 12, and 24 h after the third dose. The micafungin disposition was predominantly intracellular, with approximately 106% penetration into alveolar macrophages and 5% penetration into epithelial lining fluid.

引用

页码：1218 / 1220

页数：3

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