Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice

被引:64
作者
Suarez-Pinzon, W. L. [1 ]
Cembrowski, G. S. [2 ]
Rabinovitch, A. [1 ]
机构
[1] Univ Alberta, Dept Med, Edmonton, AB T6G 2E1, Canada
[2] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2E1, Canada
关键词
Dipeptidyl peptidase-4; Gastrin Glucagon-like peptide-1; NOD mice Proton pump inhibitor; Type; 1; diabetes; GLUCAGON-LIKE PEPTIDE-1; BETA-CELL SURVIVAL; NOD MICE; IV; HYPERGASTRINEMIA;
D O I
10.1007/s00125-009-1390-z
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:1680 / 1682
页数:3
相关论文
共 11 条
[1]
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes [J].
Drucker, Daniel J. ;
Nauck, Michael A. .
LANCET, 2006, 368 (9548) :1696-1705
[2]
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors [J].
Hansotia, T ;
Baggio, LL ;
Delmeire, D ;
Hinke, SA ;
Yamada, Y ;
Tsukiyama, K ;
Seino, Y ;
Holst, JJ ;
Schuit, F ;
Drucker, DJ .
DIABETES, 2004, 53 (05) :1326-1335
[3]
Randomized prospective trial of the effect of induced hypergastrinemia on the prevention of pancreatic atrophy after pancreatoduodenectomy in humans [J].
Jang, JY ;
Kim, SW ;
Han, JK ;
Park, SJ ;
Park, YC ;
Ahn, YJ ;
Park, YH .
ANNALS OF SURGERY, 2003, 237 (04) :522-529
[4]
DEGRADATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE AND TRUNCATED GLUCAGON-LIKE PEPTIDE-1 IN-VITRO AND IN-VIVO BY DIPEPTIDYL PEPTIDASE-IV [J].
KIEFFER, TJ ;
MCINTOSH, CHS ;
PEDERSON, RA .
ENDOCRINOLOGY, 1995, 136 (08) :3585-3596
[5]
Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation [J].
Kim, Su-Jin ;
Nian, Cuilan ;
Doudet, Doris J. ;
McIntosh, Christopher H. S. .
DIABETES, 2009, 58 (03) :641-651
[6]
Maida A, 2008, DIABETOLOGIA, V51, pS363
[7]
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic β-cell mass and function in a rodent model of type 2 diabetes [J].
Mu, James ;
Woods, John ;
Zhou, Yun-Ping ;
Roy, Ranabir Sinha ;
Li, Zhihua ;
Zycband, Emanuel ;
Feng, Yue ;
Zhu, Lan ;
Li, Cai ;
Howard, Andrew D. ;
Moller, David. E. ;
Thornberry, Nancy A. ;
Zhang, Bei B. .
DIABETES, 2006, 55 (06) :1695-1704
[8]
Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4 [J].
Ogawa, N ;
List, JF ;
Habener, JF ;
Maki, T .
DIABETES, 2004, 53 (07) :1700-1705
[9]
Dipeptidyl peptidase IV inhibitor treatment stimulates β-cell survival and islet neogenesis in streptozotocin-induced diabetic rats [J].
Pospisilik, JA ;
Martin, J ;
Doty, T ;
Ehses, JA ;
Pamir, N ;
Lynn, FC ;
Piteau, S ;
Demuth, HU ;
McIntosh, CHS ;
Pederson, RA .
DIABETES, 2003, 52 (03) :741-750
[10]
Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice [J].
Suarez-Pinzon, Wilma L. ;
Power, Robert F. ;
Yan, Yanhua ;
Wasserfall, Clive ;
Atkinson, Mark ;
Rabinovitch, Alex .
DIABETES, 2008, 57 (12) :3281-3288