Chk1 in the DNA damage response: conserved roles from yeasts to mammals

被引：153

作者：

Chen, YH ^{[1
]}

Sanchez, Y ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

关键词：

DNA damage response; genomic integrity; transduction; cell cycle; checkpoint; kinase;

D O I：

10.1016/j.dnarep.2004.03.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Chk1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. Studies to date have revealed striking similarities among Chk1 pathways of different organisms. In this review we discuss what is known about Chk1 activation and what downstream factors are regulated by Chk1 to counter replication blocks and DNA damage induced by UV, IR, and other genotoxic agents. Where applicable. we also compare the role of Chk1 with that of the Chk2 protein kinase in the checkpoint responses. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1025 / 1032

页数：8

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