Parkinson's disease and dementia with Lewy bodies: a difference in dose?

被引:54
作者
Singleton, A [1 ]
Gwinn-Hardy, K
机构
[1] NIA, Mol Genet Sect, Neurogenet Lab, NIH, Bethesda, MD 20892 USA
[2] NINDS, Parkinsons Unit, Neurogenet Branch, NIH, Bethesda, MD USA
关键词
D O I
10.1016/S0140-6736(04)17117-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1105 / 1107
页数:3
相关论文
共 10 条
[1]   Effect of allelic variation at the NACP-Rep1 repeat upstream of the α-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system [J].
Chiba-Falek, O ;
Nussbaum, RL .
HUMAN MOLECULAR GENETICS, 2001, 10 (26) :3101-3109
[2]   Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications [J].
Farrer, M ;
Kachergus, J ;
Forno, L ;
Lincoln, S ;
Wang, DS ;
Hulihan, M ;
Maraganore, D ;
Gwinn-Hardy, K ;
Wszolek, Z ;
Dickson, D ;
Langston, JW .
ANNALS OF NEUROLOGY, 2004, 55 (02) :174-179
[3]   α-synuclein gene haplotypes are associated with Parkinson's disease [J].
Farrer, M ;
Maraganore, DM ;
Lockhart, P ;
Singleton, A ;
Lesnick, TG ;
de Andrade, M ;
West, A ;
de Silva, R ;
Hardy, J ;
Hernandez, D .
HUMAN MOLECULAR GENETICS, 2001, 10 (17) :1847-1851
[4]   Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease [J].
Krüger, R ;
Kuhn, W ;
Müller, T ;
Woitalla, D ;
Graeber, M ;
Kösel, S ;
Przuntek, H ;
Epplen, JT ;
Schöls, L ;
Riess, O .
NATURE GENETICS, 1998, 18 (02) :106-108
[5]   α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication [J].
Miller, DW ;
Hague, SM ;
Clarimon, J ;
Baptista, M ;
Gwinn-Hardy, K ;
Cookson, MR ;
Singleton, AB .
NEUROLOGY, 2004, 62 (10) :1835-1838
[6]   Hereditary form of parkinsonism-dementia [J].
Muenter, MD ;
Forno, LS ;
Hornykiewicz, O ;
Kish, SJ ;
Maraganore, DM ;
Caselli, RJ ;
Okazaki, H ;
Howard, FM ;
Snow, BJ ;
Calne, DB .
ANNALS OF NEUROLOGY, 1998, 43 (06) :768-781
[7]   Mutation in the alpha-synuclein gene identified in families with Parkinson's disease [J].
Polymeropoulos, MH ;
Lavedan, C ;
Leroy, E ;
Ide, SE ;
Dehejia, A ;
Dutra, A ;
Pike, B ;
Root, H ;
Rubenstein, J ;
Boyer, R ;
Stenroos, ES ;
Chandrasekharappa, S ;
Athanassiadou, A ;
Papapetropoulos, T ;
Johnson, WG ;
Lazzarini, AM ;
Duvoisin, RC ;
DiIorio, G ;
Golbe, LI ;
Nussbaum, RL .
SCIENCE, 1997, 276 (5321) :2045-2047
[8]   The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases [J].
Singleton, A ;
Myers, A ;
Hardy, J .
HUMAN MOLECULAR GENETICS, 2004, 13 :R123-R126
[9]   α-synuclein locus triplication causes Parkinson's disease [J].
Singleton, AB ;
Farrer, M ;
Johnson, J ;
Singleton, A ;
Hague, S ;
Kachergus, J ;
Hulihan, M ;
Peuralinna, T ;
Dutra, A ;
Nussbaum, R ;
Lincoln, S ;
Crawley, A ;
Hanson, M ;
Maraganore, D ;
Adler, C ;
Cookson, MR ;
Muenter, M ;
Baptista, M ;
Miller, D ;
Blancato, J ;
Hardy, J ;
Gwinn-Hardy, K .
SCIENCE, 2003, 302 (5646) :841-841
[10]   alpha-synuclein in Lewy bodies [J].
Spillantini, MG ;
Schmidt, ML ;
Lee, VMY ;
Trojanowski, JQ ;
Jakes, R ;
Goedert, M .
NATURE, 1997, 388 (6645) :839-840