A simple method for the synthesis of 2'-O-alkylguanosine derivatives

被引：16

作者：

Grotli, M ^{[1
]}

Douglas, M ^{[1
]}

Beijer, B ^{[1
]}

Eritja, R ^{[1
]}

Sproat, B ^{[1
]}

机构：

[1] VPI GMBH,D-37124 ROSDORF,GERMANY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(97)00024-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new synthetic route has been devised for the preparation of 2'-O-alkyl guanosine derivatives. Utilizing a strategy of minimal protection, the alkylation was performed on partly protected guanosine using an alkyl halide and a sterically hindered strong organic base. (C) 1997, Elsevier Science Ltd.

引用

页码：425 / 428

页数：4

共 14 条

[1] CHEMICAL MODIFICATION OF HAMMERHEAD RIBOZYMES - CATALYTIC ACTIVITY AND NUCLEASE RESISTANCE
BEIGELMAN, L
MCSWIGGEN, JA
DRAPER, KG
GONZALEZ, C
JENSEN, K
KARPEISKY, AM
MODAK, AS
MATULICADAMIC, J
DIRENZO, AB
HAEBERLI, P
SWEEDLER, D
TRACZ, D
GRIMM, S
WINCOTT, FE
THACKRAY, VG
USMAN, N
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) : 25702 - 25708
[2] SIMPLIFIED AND COST-EFFECTIVE SYNTHESES OF FULLY PROTECTED PHOSPHORAMIDITE MONOMERS SUITABLE FOR THE ASSEMBLY OF OLIGO(2'-O-ALLYLRIBONUCLEOTIDES)
BEIJER, B
GROTLI, M
DOUGLAS, ME
SPROAT, BS
[J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1994, 13 (09) : 1905 - 1927
[3] CHANTELOUP L, 1994, TETRAHEDRON LETT, P877
[4] COTTEN M, 1993, NUCLEIC ACIDS RES, V19, P2629
[5] NEW GUANOSINE DERIVATIVES - FACILE O-6-PHOSPHORYLATION, THIOPHOSPHINYLATION SULFONYLATION AND SILYLATION OF GUANOSINE DERIVATIVES BY 4-DIMETHYLAMINOPYRIDINE CATALIZED REACTION
DASKALOV, HP
SEKINE, M
HATA, T
[J]. TETRAHEDRON LETTERS, 1980, 21 (40) : 3899 - 3902
[6] SIMPLIFIED SYNTHESIS OF 2'-O-ALKYL RIBOPYRIMIDINES
HODGE, RP
SINHA, ND
[J]. TETRAHEDRON LETTERS, 1995, 36 (17) : 2933 - 2936
[7] MARKIEWICZ WT, 1979, J CHEM RES-S, P24
[8] AMIDINE PROTECTING GROUPS FOR OLIGONUCLEOTIDE SYNTHESIS .16.
MCBRIDE, LJ
KIERZEK, R
BEAUCAGE, SL
CARUTHERS, MH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2040 - 2048
[9] NUCLEASE RESISTANT RIBOZYMES WITH HIGH CATALYTIC ACTIVITY
PAOLELLA, G
SPROAT, BS
LAMOND, AI
[J]. EMBO JOURNAL, 1992, 11 (05) : 1913 - 1919
[10] ROBINS M, 1986, J ORG CHEM, V39, P1891

← 1 2 →