Improving vaccines by targeting antigens to dendritic cells

被引：80

作者：

Shortman, Ken ^{[1
]}

Lahoud, Mireille H. ^{[1
]}

Caminschi, Irina ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2009年 / 41卷 / 02期

关键词：

adjuvants; immunologic; antibody formation; CLEC9a protein; human; DEC-205; receptor; dendritic cells; vaccines; SUBSETS IN-VIVO; C-TYPE LECTIN; STEADY-STATE; T-CELLS; CROSS-PRESENTATION; IFN-GAMMA; CD8(+); RESPONSES; IMMUNITY; CD4;

D O I：

10.3858/emm.2009.41.2.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new approach to enhancing the effectiveness of vaccines is to deliver antigens selectively to dendritic cells (DC) in situ, via monoclonal antibodies specific for particular DC surface molecules. This can markedly enhance CTL responses and, via helper T cells, also enhance antibody responses. DC activation agents or adjuvants must also be administered for effective CTL responses, but in some cases good antibody responses can be obtained without adjuvants. Here we review the role of different DC subsets and different DC target molecules in obtaining enhanced immune responses.

引用

页码：61 / 66

页数：6

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