An experimental study of the variability in the properties and quality of wet granules

被引：42

作者：

Fu, JS

Cheong, YS

Reynolds, GK

Adams, MJ

Salman, AD

Hounslow, MJ

机构：

[1] Univ Sheffield, Dept Chem & Proc Engn, Particle Prod Grp, Sheffield S1 3JD, S Yorkshire, England

[2] Univ Birmingham, Ctr Formulat Engn Chem Engn, Birmingham B15 2TT, W Midlands, England

来源：

POWDER TECHNOLOGY | 2004年 / 140卷 / 03期

关键词：

high-shear mixer; granule quality; restitution coefficient; granule porosity; granule appearance;

D O I：

10.1016/j.powtec.2004.01.019

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

For wet high-shear granulation, there can be a considerable variability in product quality in terms of the size, binder content, porosity, and appearance. Using the same equipment and feed material, it has been shown that such variability can be reduced by optimising the operating protocol. The associated narrowing of the range of mechanical properties for granules formed using an optimised procedure is exemplified by measurements of a number of parameters such as the coefficient of restitution. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：209 / 216

页数：8

共 11 条

[1] WET SPHERICAL AGGLOMERATION OF PROTEINS AS A NEW METHOD TO PREPARE PARENTERAL FAST SOLUBLE DOSAGE FORMS [J].