Histone acetylation and reactivation of Epstein-Barr virus from latency

被引：110

作者：

Jenkins, PJ

Binné, UK

Farrell, PJ

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ludwig Inst Canc Res, London W2 1PG, England

[2] Univ London Imperial Coll Sci Technol & Med, Virol & Cell Biol Sect, London W2 1PG, England

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 02期

关键词：

D O I：

10.1128/JVI.74.2.710-720.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Induction of the viral BZLF1 gene has previously been shown to be one of the first steps in the reactivation of Epstein-Barr virus (EBV). Using an EBV oriP episomal vector system, we have reconstituted the regulation of the promoter for BZLF1 on stably transfected episomes, mapped promoter elements required for that regulation, and investigated mechanisms that may control the switch between latency and the lytic cycle. Changes in histone acetylation at the promoter for the BZLF1 gene appear to be a key part of the reactivation mechanism of this herpesvirus.

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页码：710 / 720

页数：11

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