Liver injury after beginning antiretroviral therapy in HIV/hepatitis C virus co-infected patients is not related to immune reconstitution

被引：33

作者：

Martín-Carbonero, L ^{[1
]}

Núñez, M ^{[1
]}

Ríos, P ^{[1
]}

Pérez-Olmeda, M ^{[1
]}

González-Lahoz, J ^{[1
]}

Soriano, V ^{[1
]}

机构：

[1] Hosp Carlos 3, Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain

来源：

AIDS | 2002年 / 16卷 / 10期

关键词：

D O I：

10.1097/00002030-200207050-00016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transaminase elevations occur more frequently after beginning antiretroviral therapy in HIV-positive patients co-infected with hepatitis C virus (HCV). The mechanism of liver injury in these individuals is unknown, although immune reconstitution phenomena have been postulated. In 42 HIV/HCV co-infected individuals followed after beginning potent antiretroviral therapy, the development of liver injury was not associated with significant changes in serum HCV-RNA levels nor with greater CD4 cell increases. Underlying chronic hepatitis may thus increase the risk of liver toxicity by other mechanisms.

引用

页码：1423 / 1425

页数：3

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