The diploid genome sequence of Candida albicans

被引：562

作者：

Jones, T

Federspiel, NA

Chibana, H

Dungan, J

Kalman, S

Magee, BB

Newport, G

Thorstenson, YR

Agabian, N

Magee, PT

Davis, RW ^{[1
]}

Scherer, S

机构：

[1] Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

[2] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chiba 2608673, Japan

[3] Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[6] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 19期

关键词：

D O I：

10.1073/pnas.0401648101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.

引用

页码：7329 / 7334

页数：6

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