Experimental diabetes upregulates the expression of ureteral endothelin receptors

被引：11

作者：

Nakamura, I ^{[1
]}

Saito, M ^{[1
]}

Fukumoto, Y ^{[1
]}

Yoshida, M ^{[1
]}

Nishi, K ^{[1
]}

Weiss, RM ^{[1
]}

Latifpour, J ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,UROL SECT,NEW HAVEN,CT 06520

来源：

PEPTIDES | 1997年 / 18卷 / 07期

关键词：

endothelin receptor; diabetes; ureter; rat;

D O I：

10.1016/S0196-9781(97)00026-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the binding characteristics of endothelin (ET) receptors in the ureters of rats with experimentally induced diabetes and diuresis. Receptor binding experiments demonstrated an upregulation in the expression of [I-125]ET-1 binding sites in the diabetic rat ureter but not in the diuretic rat ureter. ET-I, ET-3, IRL 1620, and BQ 610 inhibited [I-125]ET-binding to the rat ureter consistent with the predominance of ETA receptors in these tissues. The subtype specificity of ET receptors in ureteral tissues was confirmed with inhibition data obtained from cloned human ETA and ETB receptors. (C) 1997 Elsevier Science Inc.

引用

页码：1091 / 1093

页数：3

共 11 条

[1] CLONING AND EXPRESSION OF A CDNA-ENCODING AN ENDOTHELIN RECEPTOR [J].