Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010

被引：22

作者：

Cho, Eun Young ^{[1
,2
]}

Lee, Hyunju ^{[3
]}

Choi, Eun Hwa ^{[1
]}

Kim, Yae-Jean ^{[4
]}

Eun, Byung Wook ^{[5
]}

Cho, Yong Kyun ^{[6
]}

Kim, Yun-Kyung ^{[7
]}

Jo, Dae Sun ^{[8
]}

Lee, Hye Soo ^{[9
]}

Lee, Jina ^{[10
,11
]}

Kim, Mi-Na ^{[11
,12
]}

Kim, Dong Soo ^{[13
]}

Lee, Hoan Jong ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Childrens Hosp, Dept Pediat, Seoul, South Korea

[2] Chungnam Natl Univ Hosp, Dept Pediat, Taejon, South Korea

[3] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Pediat, Songnam, South Korea

[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea

[5] Eulji Univ, Sch Med, Eulji Gen Hosp, Dept Pediat, Seoul, South Korea

[6] Gachon Univ, Gil Hosp, Sch Med, Dept Internal Med, Inchon, South Korea

[7] Korea Univ, Ansan Hosp, Coll Med, Dept Pediat, Ansan, South Korea

[8] Chonbuk Natl Univ, Chonbuk Natl Univ Hosp, Sch Med, Dept Pediat, Jeonju, South Korea

[9] Chonbuk Natl Univ, Chonbuk Natl Univ Hosp, Sch Med, Dept Lab Med, Jeonju, South Korea

[10] Univ Ulsan, Coll Med, Dept Pediat, Seoul, South Korea

[11] Asan Med Ctr, Seoul, South Korea

[12] Univ Ulsan, Coll Med, Dept Lab Med, Seoul, South Korea

[13] Yonsei Univ, Coll Med, Severance Childrens Hosp, Dept Pediat, Seoul, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2014年 / 78卷 / 04期

关键词：

Streptococcus pneumoniae; Serotype; Antimicrobial resistance; Pneumococcal vaccines; PNEUMOCOCCAL DISEASE; CHILDREN; 19A; PREVALENCE;

D O I：

10.1016/j.diagmicrobio.2013.12.016

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：481 / 486

页数：6

共 22 条

[1]

[Anonymous], 2000, MMWR Recomm Rep, V49, P1

[2] Comparison of genotypes of Streptococcus pneumoniae serotypes 6A and 6B before and after the introduction of PCV7 vaccination in Korea [J].