Pd-catalyzed kinetic resolution of benzylic alcohols:: a practical synthesis of (R)-tomoxetine and (S)-fluoxetine hydrochlorides

被引：46

作者：

Ali, IS ^{[1
]}

Sudalai, A ^{[1
]}

机构：

[1] Natl Chem Lab, Div Proc Dev, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 31期

关键词：

resolution; oxidation; asymmetric synthesis; alcohols;

D O I：

10.1016/S0040-4039(02)01073-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthetic route to (R)-tomoxetine hydrochloride (90% ee) and (S)-fluoxetine hydrochloride (84% ee) is described. (S)-3-Phenyl-3-hydroxypropyl p-toluenesulphonate, the key intermediate, is obtained by the oxidative kinetic resolution of the corresponding racemic 3-phenyl-3-hydroxypropyl p-toluenesulphonate using (-)-sparteine/Pd(II)/O-2 (1 atm) catalytic system. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：5435 / 5436

页数：2

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