Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions

被引：218

作者：

Hazan, R ^{[1
]}

Sat, B ^{[1
]}

Engelberg-Kulka, H ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Biol Mol, IL-91120 Jerusalem, Israel

来源：

JOURNAL OF BACTERIOLOGY | 2004年 / 186卷 / 11期

关键词：

D O I：

10.1128/JB.186.11.3663-3669.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.

引用

页码：3663 / 3669

页数：7

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