Photodynamic therapy of superficial basal cell carcinomas using exogenous 5-aminolevulinic acid and 514-nm light

被引:3
作者
Alvanopoulos, K [1 ]
Antoniou, C [1 ]
Melpo, P [1 ]
Vareltzidis, A [1 ]
Katsambas, A [1 ]
机构
[1] A SYGROS HOSP, DEPT PHOTOBIOL, ATHENS, GREECE
关键词
photodynamic therapy; 5-ALA; 514; nm; laser;
D O I
10.1016/S0926-9959(97)00093-7
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Objective The evaluation of the effectiveness of topical photodynamic therapy with 5-aminolevulinic acid (5-ALA) and green laser light on superficial basal cell carcinomas. Background Topical photodynamic therapy with exogenous 5-ALA and visible or red laser light has been used up to now for the treatment of superficial non-melanoma skin tumors. Patients and methods Four patients with nine superficial carcinomas participated in this study. The tumors were irradiated with green laser light 5 h after the application of cold cream with 20% aminolevulinic acid under occlusive dressing. Results All nine lesions were resolved with a single treatment and clinical evidence of recurrence was observed in one tumor 1 year after the therapy. Conclusion Topical photodynamic therapy with exogenous 5-ALA and preen laser light is very effective for superficial basal cell carcinomas. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:134 / 136
页数:3
相关论文
共 15 条
[1]   PORPHYRIN SENSITIZED PHOTOTHERAPY [J].
BERNS, MW ;
MCCULLOUGH, JL .
ARCHIVES OF DERMATOLOGY, 1986, 122 (08) :871-874
[2]  
BERNSTEIN E F, 1990, Archives of Dermatology, V126, P1303, DOI 10.1001/archderm.126.10.1303
[3]   PHOTORADIATION THERAPY FOR CUTANEOUS AND SUBCUTANEOUS MALIGNANCIES [J].
DOUGHERTY, TJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1981, 77 (01) :122-124
[4]  
GOFF AB, 1992, J PHOTOCHEM PHOTOBIO, V14, P239
[5]  
HENDERSON BW, 1989, PHOTODERMATOLOGY, V6, P200
[6]  
HUTTMANN G, 1992, LASER MED, V8, P227
[7]   PHOTODYNAMIC THERAPY IN THE TREATMENT OF BOWENS DISEASE [J].
JONES, CM ;
MANG, T ;
COOPER, M ;
WILSON, BD ;
STOLL, HL .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1992, 27 (06) :979-982
[8]   ENDOGENOUS PROTOPORPHYRIN-IX, A CLINICALLY USEFUL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY [J].
KENNEDY, JC ;
POTTIER, RH .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1992, 14 (04) :275-292
[9]  
KESSEL D, 1989, PHOTODERMATOLOGY, V6, P197
[10]   NONINVASIVE TECHNIQUE FOR OBTAINING FLUORESCENCE EXCITATION AND EMISSION-SPECTRA INVIVO [J].
POTTIER, RH ;
CHOW, YFA ;
LAPLANTE, JP ;
TRUSCOTT, TG ;
KENNEDY, JC ;
BEINER, LA .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1986, 44 (05) :679-687