New pregnane glycosides from Caralluma negevensis

被引：40

作者：

Braca, A

Bader, A

Morelli, I

Scarpato, R

Turchi, G

Pizza, C

De Tommasi, N

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

[2] Univ Pisa, Dipartimento Chim Bioorgan & Biofarm, I-56126 Pisa, Italy

[3] Univ Pisa, Dipartimento Sci Uomo & Ambiente, I-56126 Pisa, Italy

[4] CNR, Ist Mutagenesi & Differenziamento, Area Ric, I-56126 Pisa, Italy

来源：

TETRAHEDRON | 2002年 / 58卷 / 29期

关键词：

pregnane glycosides; Caralluma negevensis; cytotoxicity; genotoxicity;

D O I：

10.1016/S0040-4020(02)00563-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Twenty new pregnane glycosides were isolated from the whole plant of Caralluma negevensis. Their structures were elucidated by extensive spectroscopic methods including 1D-(H-1, C-13, C-13 DEPT, TOCSY, ROESY) and 2D-NMR experiments (DQF-COSY, HSQC, HMBC, HOHAHA) as well as ESI-MS analysis. Pregnane glycosides were tested for their cytotoxic and genotoxic activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5837 / 5848

页数：12

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