Beclin 1: a BH3-only protein that fails to induce apoptosis

被引：31

作者：

Boya, P. ^{[1
]}

Kroemer, G. ^{[2
,3
,4
]}

机构：

[1] Consejo Super Invest Cient, Ctr Invest Biol, Lab 3D, Dept Cellular & Mol Physiopathol, E-28040 Madrid, Spain

[2] INSERM, U848, Villejuif, France

[3] Inst Gustave Roussy, F-94805 Villejuif, France

[4] Univ Paris 11, Villejuif, France

来源：

ONCOGENE | 2009年 / 28卷 / 21期

关键词：

autophagy; apoptosis; Bcl-2; Beclin-1; endoplasmic reticulum; mitochondria; BCL-XL; AUTOPHAGY; COMPLEX; DOMAIN;

D O I：

10.1038/onc.2009.83

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy. Oncogene (2009) 28, 2125-2127; doi: 10.1038/onc.2009.83; published online 27 April 2009

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收藏

页码：2125 / 2127

页数：3

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