15NH4+ ion movement inside d(G4T4G4)2 G-quadruplex is accelerated in the presence of smaller Na+ ions

被引：29

作者：

Sket, P

Crnugelj, M

Kozminski, W

Plavec, J

机构：

[1] Natl Inst Chem, NMR Ctr, SI-1000 Ljubljana, Slovenia

[2] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 14期

关键词：

D O I：

10.1039/b406815g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2D NMR studies demonstrate that the residence lifetime of (NH4+)-N-15 ions within the bimolecular G-quadruplex adopted by d(G(4)T(4)G(4)) is reduced from 270 ms in the presence of ammonium ions alone to 36 ms in the presence of Na+ ions.

引用

页码：1970 / 1973

页数：4

共 38 条

[1] THE COHERENCE OF SYNTHETIC TELOMERES [J].

ACEVEDO, OL ;

DICKINSON, LA ;

MACKE, TJ ;

THOMAS, CA .

NUCLEIC ACIDS RESEARCH, 1991, 19 (12) :3409-3419

[2] PHYSICOCHEMICAL PROPERTIES OF NUCLEOSIDES .3. GEL FORMATION BY 8-BROMOGUANOSINE [J].

CHANTOT, JF ;

GUSCHLBAUER, W .

FEBS LETTERS, 1969, 4 (03) :173-+

[3] G-quadruplex structure can be stable with only some coordination sites being occupied by cations: A six-nanosecond molecular dynamics study [J].

Chowdhury, S ;

Bansal, M .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (31) :7572-7578

[4] Small change in a G-rich sequence, a dramatic change in topology: New dimeric G-quadruplex folding motif with unique loop orientations [J].

Crnugelj, M ;

Sket, P ;

Plavec, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (26) :7866-7871

[5] The solution structure of d(G4T4G3)2:: a bimolecular G-quadruplex with a novel fold [J].

Crnugelj, M ;

Hud, NV ;

Plavec, J .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 320 (05) :911-924

[6] G-quartets 40 years later:: From 5′-GMP to molecular biology and supramolecular chemistry [J].

Davis, JT .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (06) :668-698

[7] Kinetics of sodium ion binding to DNA quadruplexes [J].

Deng, H ;

Braunlin, WH .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 255 (03) :476-483

[8] Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing [J].

Gomez, D ;

Lemarteleur, T ;

Lacroix, L ;

Mailliet, P ;

Mergny, JL ;

Riou, JF .

NUCLEIC ACIDS RESEARCH, 2004, 32 (01) :371-379

[9] Crystal structure of the potassium form of an Oxytricha nova G-quadruplex [J].

Haider, S ;

Parkinson, GN ;

Neidle, S .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 320 (02) :189-200

[10]

Hardin CC, 2001, BIOPOLYMERS, V56, P147, DOI 10.1002/1097-0282(2000/2001)56:3<147::AID-BIP10011>3.0.CO

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