Galactosylated N-vinylpyrrolidone-maleic acid copolymers:: Synthesis, characterization, and interaction with lectins

被引：36

作者：

Auzély-Velty, R

Cristea, M

Rinaudo, M

机构：

[1] Ctr Rech Macromol Vegetales, F-38041 Grenoble 9, France

[2] Romanian Acad, Petru Poni Inst Macromol Chem, Iasi 6600, Romania

来源：

BIOMACROMOLECULES | 2002年 / 3卷 / 05期

关键词：

D O I：

10.1021/bm020035m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Water-soluble artificial glycoconjugate polymers were synthesized from poly(N-vinylpyrrolidone-co-maleic anhydride) by amidation with an amine-containing galactose derivative. The glycopolymers having different galactose contents were fully characterized in terms of chemical structure by NMR and potentiometric titrations, and their aqueous behavior was studied by viscometric measurements. Their specific binding properties were examined by enzyme-linked lectin assays using RCA(120) lectin. Whatever the glycopolymer, the grafted galactoses were shown to behave similarly to free galactose.

引用

页码：998 / 1005

页数：8

共 18 条

[1] Behavior of nonalternating maleic acid copolymers in aqueous solution [J].