Cutting edge:: Murine dendritic cells require IL-15Rα to prime NK cells

被引：156

作者：

Koka, R ^{[1
]}

Burkett, P ^{[1
]}

Chien, M ^{[1
]}

Chai, S ^{[1
]}

Boone, DL ^{[1
]}

Ma, A ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF IMMUNOLOGY | 2004年 / 173卷 / 06期

关键词：

D O I：

10.4049/jimmunol.173.6.3594

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NK cells protect hosts against viral pathogens and transformed cells, and dendritic cells (DCs) play important roles inactivating NK cells. We now find that murine IL15Ralpha-deficient DCs fail to support NK cell cytolytic activity and elaboration of IFN-gamma, despite the fact that these DCs express normal levels of costimulatory molecules and IL-12. By contrast, IL-15Ralpha expression on NK cells is entirely dispensible for their activation by DCs. In addition, blockade with anti-IL-15Ralphaandanti-IL-2Rbeta butnotanti-IL-2Ralpha-specific Abs prevents NK cell activation by wildtype DO. Finally, presentation of IL-15 by purified IL15Ralpha/Fc in trans synergizes with IL-12 to support NK cell priming. These findings suggest that murine DCs require IL-15Ralpha to present IL-15 in trans to NKcells during NK cell priming.

引用

页码：3594 / 3598

页数：5

共 31 条

[1] THE INTERLEUKIN (IL)-2 RECEPTOR-BETA CHAIN IS SHARED BY IL-2 AND A CYTOKINE, PROVISIONALLY DESIGNATED IL-T, THAT STIMULATES T-CELL PROLIFERATION AND THE INDUCTION OF LYMPHOKINE-ACTIVATED KILLER-CELLS
BAMFORD, RN
GRANT, AJ
BURTON, JD
PETERS, C
KURYS, G
GOLDMAN, CK
BRENNAN, J
ROESSLER, E
WALDMANN, TA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) : 4940 - 4944
[2] Beckett S, 2002, CALL CENT MAG, V15, P8
[3] IL-15Rα expression on CD8+ T cells is dispensable for T cell memory
Burkett, PR
Koka, R
Chien, M
Chai, S
Chan, F
Ma, A
Boone, DL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) : 4724 - 4729
[4] Natural killer cell activation in mice and men: different triggers for similar weapons?
Colucci, F
Di Santo, JP
Leibson, PJ
[J]. NATURE IMMUNOLOGY, 2002, 3 (09) : 807 - 813
[5] Comes A, 2002, EUR J IMMUNOL, V32, P1914, DOI 10.1002/1521-4141(200207)32:7<1914::AID-IMMU1914>3.0.CO
[6] 2-P
[7] NK cell and DC interactions
Cooper, MA
Fehniger, TA
Fuchs, A
Colonna, M
Caligiuri, MA
[J]. TRENDS IN IMMUNOLOGY, 2004, 25 (01) : 47 - 52
[8] In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells
Cooper, MA
Bush, JE
Fehniger, TA
VanDeusen, JB
Waite, RE
Liu, Y
Aguila, HL
Caligiuri, MA
[J]. BLOOD, 2002, 100 (10) : 3633 - 3638
[9] IL-15Rα recycles and presents IL-15 in trans to neighboring cells
Dubois, S
Mariner, J
Waldmann, TA
Tagaya, Y
[J]. IMMUNITY, 2002, 17 (05) : 537 - 547
[10] Fawaz LM, 1999, J IMMUNOL, V163, P4473

← 1 2 3 4 →