Serpents on the road to dementia and death

被引：13

作者：

Beyreuther, K ^{[1
]}

Masters, CL ^{[1
]}

机构：

[1] UNIV MELBOURNE, DEPT PATHOL, PARKVILLE, VIC 3025, AUSTRALIA

来源：

NATURE MEDICINE | 1997年 / 3卷 / 07期

关键词：

D O I：

10.1038/nm0797-723

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulating evidence from several studies points to the normal function of presenilin 1 and suggests how the mutant protein contributes to deposition of amyloid plaques in Alzheimer's disease (pages 756–760).

引用

页码：723 / 725

页数：3

共 12 条

[1] BOTTO M, IN PRESS NATURE MED
[2] RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease (Retracted Article)
Davis, RE
Miller, S
Herrnstadt, C
Ghosh, SS
Fahy, E
Shinobu, LA
Galasko, D
Thal, LJ
Beal, MF
Howell, N
Parker, WD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) : 4526 - 4531
[3] Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1
Duff, K
Eckman, C
Zehr, C
Yu, X
Prada, CM
Pereztur, J
Hutton, M
Buee, L
Harigaya, Y
Yager, D
Morgan, D
Gordon, MN
Holcomb, L
Refolo, L
Zenk, B
Hardy, J
Younkin, S
[J]. NATURE, 1996, 383 (6602) : 710 - 713
[4] Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Joutel, A
Corpechot, C
Ducros, A
Vahedi, K
Chabriat, H
Mouton, P
Alamowitch, S
Domenga, V
Cecillion, M
Marechal, E
Maciazek, J
Vayssiere, C
Cruaud, C
Cabanis, EA
Ruchoux, MM
Weissenbach, J
Bach, JF
Bousser, MG
TournierLasserve, E
[J]. NATURE, 1996, 383 (6602) : 707 - 710
[5] Hyperaccumulation of FAD-linked presenilin 1 variants in vivo
Lee, MK
Borchelt, DR
Kim, G
Thinakaran, G
Slunt, HH
Ratovitski, T
Martin, LJ
Kittur, A
Gandy, S
Levey, AI
Jenkins, N
Copeland, N
Price, DL
Sisodia, SS
[J]. NATURE MEDICINE, 1997, 3 (07) : 756 - 760
[6] Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
Nalbantoglu, J
TiradoSantiago, G
Lahsaini, A
Poirier, J
Goncalves, O
Verge, A
Momoli, F
Welner, SA
Massicotte, G
Julien, JP
Shapiro, ML
[J]. NATURE, 1997, 387 (6632) : 500 - 505
[7] Sandbrink R, 1996, MOL PSYCHIATR, V1, P27
[8] Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
Scheuner, D
Eckman, C
Jensen, M
Song, X
Citron, M
Suzuki, N
Bird, TD
Hardy, J
Hutton, M
Kukull, W
Larson, E
LevyLahad, E
Viitanen, M
Peskind, E
Poorkaj, P
Schellenberg, G
Tanzi, R
Wasco, W
Lannfelt, L
Selkoe, D
Younkin, S
[J]. NATURE MEDICINE, 1996, 2 (08) : 864 - 870
[9] Skeletal and CNS defects in Presenilin-1-deficient mice
Shen, J
Bronson, RT
Chen, DF
Xia, WM
Selkoe, DJ
Tonegawa, S
[J]. CELL, 1997, 89 (04) : 629 - 639
[10] Tienari PJ, 1996, COLD SPRING HARB SYM, V61, P575

← 1 2 →