Parkinson's disease

被引：1069

作者：

Samii, A

Nutt, JG

Ransom, BR

机构：

[1] VA Puget Sound Hlth Care Syst, NW Parkinson Dis Res Educ & Clin Ctr, Seattle, WA 98108 USA

[2] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA

[3] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

[4] Portland VA Med Ctr, NW Parkinson Dis Res Educ & Clin Ctr, Portland, OR USA

来源：

LANCET | 2004年 / 363卷 / 9423期

关键词：

D O I：

10.1016/S0140-6736(04)16305-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Parkinson's disease is the most common serious movement disorder in the world, affecting about 1% of adults older than 60 years. The disease is attributed to selective loss of neurons in the substantia nigra, and its cause is enigmatic in most individuals. Symptoms of Parkinson's disease respond in varying degrees to drugs, and surgery offers hope for patients no longer adequately controlled in this manner. The high prevalence of the disease, and important advances in its management, mean that generalists need to have a working knowledge of this disorder. This Seminar covers the basics, from terminology to aspects of diagnosis, treatment, and pathogenesis.

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收藏

页码：1783 / 1793

页数：11

相关论文

共 158 条

[1] Donepezil for cognitive impairment in Parkinson's disease: a randomised controlled study [J].

Aarsland, D ;

Laake, K ;

Larsen, JP ;

Janvin, C .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2002, 72 (06) :708-712

[2] A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe [J].

Abbas, N ;

Lücking, CB ;

Ricard, S ;

Dürr, A ;

Bonifati, V ;

De Michele, G ;

Bouley, S ;

Vaughan, JR ;

Gasser, T ;

Marconi, R ;

Broussolle, E ;

Brefel-Courbon, C ;

Harhangi, BS ;

Oostra, AB ;

Fabrizio, E ;

Böhme, GA ;

Pradier, L ;

Wood, NW ;

Filla, A ;

Meco, G ;

Denefle, P ;

Agid, Y ;

Brice, A .

HUMAN MOLECULAR GENETICS, 1999, 8 (04) :567-574

[3] Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson's disease [J].

Adler, CH ;

Caviness, JN ;

Hentz, JG ;

Lind, M ;

Tiede, J .

MOVEMENT DISORDERS, 2003, 18 (03) :287-293

[4] Stem cells in the treatment of Parkinson's disease [J].

Arenas, E .

BRAIN RESEARCH BULLETIN, 2002, 57 (06) :795-808

[5] Tolcapone and fulminant hepatitis [J].

Assal, F ;

Spahr, L ;

Hadengue, A ;

Rubbici-Brandt, L ;

Burkhard, PR .

LANCET, 1998, 352 (9132) :958-958

[6] Parkinson's disease and parkinsonism in a longitudinal study - Two-fold higher incidence in men [J].

Baldereschi, M ;

Di Carlo, A ;

Rocca, WA ;

Vanni, P ;

Maggi, S ;

Perissinotto, E ;

Grigoletto, F ;

Amaducci, L ;

Inzitari, D .

NEUROLOGY, 2000, 55 (09) :1358-1363

[7] Prevalence of Parkinsonian signs and associated mortality in a community population of older people [J].

Bennett, DA ;

Beckett, LA ;

Murray, AM ;

Shannon, KM ;

Goetz, CG ;

Pilgrim, DM ;

Evans, DA .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (02) :71-76

[8] Complications of deep brain stimulation surgery [J].

Beric, A ;

Kelly, PJ ;

Rezai, A ;

Sterio, D ;

Mogilner, A ;

Zonenshayn, M ;

Kopell, B .

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 2001, 77 (1-4) :73-78

[9] Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism [J].

Bonifati, V ;

Rizzu, P ;

van Baren, MJ ;

Schaap, O ;

Breedveld, GJ ;

Krieger, E ;

Dekker, MCJ ;

Squitieri, F ;

Ibanez, P ;

Joosse, M ;

van Dongen, JW ;

Vanacore, N ;

van Swieten, JC ;

Brice, A ;

Meco, G ;

van Duijn, CM ;

Oostra, BA ;

Heutink, P .

SCIENCE, 2003, 299 (5604) :256-259

[10] Clinical features of parkinsonian patients with the α-synuclein (G209A) mutation [J].

Bostantjopoulou, S ;

Katsarou, Z ;

Papadimitriou, A ;

Veletza, V ;

Hatzigeorgiou, G ;

Lees, A .

MOVEMENT DISORDERS, 2001, 16 (06) :1007-1013

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