Relation of resistin levels with cardiovascular risk factors and insulin resistance in non-diabetes obese patients

Background: The aim of the present study was to explore the relationship of resistin levels with these above mentioned factors. Subjects: A population of 213 obese was analyzed. A complete nutritional and biochemical evaluation was performed. Results: The mean age was 45.1 + 16.7 years, the mean BMI was 35.6 + 5.7. Higher weight, fat mass, fat free mass, waist to hip ratio, RMR, insulin and HOMA levels were observed in men than women. in all group, the analysis with a dependent variable (resistin) showed that fat mass remained in the model (F = 2.48; p < 0.05), with an increase of 0.033 ng/ml (CI95%: 0.011-0.055) with each 1 kg of fat mass and a decrease of -0.29 ng/ml (CI95%: -0.53, -0.01) with each mmHg of diastolic blood pressure. In a second model (only women) (resistin), fat mass remained in the model (F = 6.06; p < 0.05), with an increase of 0.037 ng/ml (CI95%: 0.015, 0.06) with each kg of fat mass and a decrease of -0.032 ng/ml (CI95%: -0.054, -0.01) with each mmHg of diastolic blood pressure. The third multivariate analysis (only men) did not show any relation among resistin levels and other parameters. Conclusion: Resistin levels are related with different cardiovascular risk and anthropometric parameters, without relation with insulin resistance. A sex interaction has been observed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.