The Association between Periodontal Disease and Chronic Obstructive Pulmonary Disease: A Case Control Study

被引:22
作者
Oztekin, Gorkem [1 ]
Baser, Ulku [1 ]
Kucukcoskun, Meric [1 ]
Tanrikulu-Kucuk, Sevda [2 ]
Ademoglu, Evin [3 ]
Isik, Gulden [1 ]
Ozkan, Gulcihan [4 ]
Yalcin, Funda [1 ]
Kiyan, Esen [5 ]
机构
[1] Istanbul Univ, Fac Dent, Dept Periodontol, TR-34390 Istanbul, Turkey
[2] Istanbul Bilim Univ, Fac Med, Dept Biochem, Istanbul, Turkey
[3] Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34390 Istanbul, Turkey
[4] Yedikule Chest Dis & Thorac Surg Training & Res H, Istanbul, Turkey
[5] Istanbul Univ, Istanbul Fac Med, Dept Pulm Dis, TR-34390 Istanbul, Turkey
关键词
pulmonary disease; chronic obstructive; periodontal disease; periodontitis; C-reactive protein; interleukin-1beta; C-REACTIVE PROTEIN; GINGIVAL CREVICULAR FLUID; SYSTEMIC INFLAMMATION; RESPIRATORY-DISEASES; BONE LOSS; HEALTH; SERUM; MANAGEMENT; RISK;
D O I
10.3109/15412555.2013.858316
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
100201 [内科学];
摘要
Introduction: Although there are studies evaluating the effects of periodontal health on chronic obstructive pulmonary disease (COPD), the effects of COPD - a systemic disease, on periodontal tissue is unknown. The aim of this study is to evaluate the effects of COPD on periodontal tissues by comparing COPD patients and controls. Methods: Fifty-two COPD patients and 38 non-COPD controls were included in this case-control study. Number of teeth, plaque index (PI), gingival index (GI), bleeding on probing, clinical attachment level and probing depth were included in the periodontal examination. In addition to clinical evaluations, gingival crevicular fluid (GCF) levels of high-sensitive C-reactive protein (hs-CRP), interleukin-1 beta (IL-1 beta) and prostaglandin-E-2 (PGE(2)), and serum hs-CRP levels were measured in COPD patients and the controls. Results: The number of teeth was significantly lower while PI and GI were significantly higher in COPD patients when compared to the controls. As well as serum hs-CRP levels, the GCF levels of hs-CRP, IL-1 beta and PGE(2) were significantly higher in COPD patients than the controls. Conclusion: Our results demonstrated that COPD may be associated with periodontal disease as manifested by lower number of teeth and higher levels of inflammatory mediators especially CRP in GCF. This finding may be a reflection of systemic effects of COPD on periodontal tissues. Poor oral health behavior of COPD patients have to be considered in larger size group studies in the future.
引用
收藏
页码:424 / 430
页数:7
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