Novel biological response modifiers: Phthalimides with tumor necrosis factor-alpha production-regulating activity

被引：112

作者：

Miyachi, H

Azuma, A

Ogasawara, A

Uchimura, E

Watanabe, N

Kobayashi, Y

Kato, F

Kato, M

Hashimoto, Y

机构：

[1] UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

[2] TOHO UNIV,FAC SCI,DEPT BIOMOL SCI,FUNABASHI,CHIBA 274,JAPAN

[3] ISHIHARA SANGYO KAISHA LTD,CENT RES INST,R&D GRP PHARMACEUT,SHIGA 525,JAPAN

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 40卷 / 18期

关键词：

D O I：

10.1021/jm970109q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel N-substituted phthalimides (2-substituted VI-isoindole-1,3-diones) were prepared, and their effects on tumor necrosis factor-alpha (TNF-alpha) production by human leukemia cell line HL-60 stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N-benzylphthalimides revealed that their enhancing effect on TPA-induced TNF-alpha production by HL-60 cells and their inhibiting effect on OA-induced TNF-alpha production by HL-60 cells are only partially correlated.

引用

页码：2858 / 2865

页数：8

共 24 条

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