THE ROLE OF DUAL-TIME COMBINED 18-FLUORIDEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY IN THE STAGING AND RESTAGING WORKUP OF LOCALLY ADVANCED RECTAL CANCER, TREATED WITH PREOPERATIVE CHEMORADIATION THERAPY AND RADICAL SURGERY

Purpose: In patients with locally advanced rectal cancer (LARC) staging and, after preoperative chemoradiation therapy (CRT), restaging workup could be useful to tailor therapeutic approaches. Fluorine-18-fluorodeoxyglucose positron emission tomography ([F-18]FDG-PET) is a promising tool for monitoring the effect of antitumor therapy. This study was aimed to evaluate the possible role of dual time sequential FDG-PET scans in the staging and restaging workup of LARC. Methods and Materials: Eighty-seven consecutive patients with LARC were enrolled. CRT consisted of external-beam intensified radiotherapy (concurrent boost), with concomitant chemotherapy PVI 5-FU (300mg/m(2)/day) followed 8-10 weeks later by surgery. All patients underwent [F-18]FDG-PET/CT before and 5-6 weeks later after the completion of CRT. Measurements of FDG uptake (SUVmax), and percentage of SUVmax difference (Response Index = RI) between pre- and post-CRT [F-18]FDG-PET scans were evaluated. Results: Six of 87 patients were excluded due to protocol deviation. Following CRT, 40/81 patients (49%) were classified as responders according to Mandard's criteria (TRG1-2). The mean pre-CRT SUVmax was significantly higher than post-CRT (15.8, vs 5.9; p < 0.001). The mean RI was significantly higher in responders than in nonresponder patients (71.3% vs 38%; p = 0.0038). Using a RI cut-off of 65% for defining response to therapy, the following parameters have been obtained: 84.5% sensitivity, 80% specificity, 81.4% positive predictive value, 84.2% negative predictive value, and 81% overall accuracy. Conclusion: These results suggest the potential role of [F-18]FDG-PET in the restaging workup after preoperative CRT in LARC. RI seems the best predictor to identify CRT response. Published by Elsevier Inc.