Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes

被引：78

作者：

Murakami, A

Nakashima, M

Koshiba, T

Maoka, T

Nishino, H

Yano, M

Sumida, T

Kim, OK

Koshimizu, K

Ohigashi, H ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Kyoto 6068502, Japan

[2] Kinki Univ, Fac Biol Oriented Sci & Technol, Dept Biotechnol Sci, Wakayama 6496493, Japan

[3] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

[5] Natl Inst Fruit Tree Sci, Shimizu, Shizuoka 4240204, Japan

[6] Ehime Citrus Res Inst Inc, Matsuyama, Ehime 7918006, Japan

来源：

CANCER LETTERS | 2000年 / 149卷 / 1-2期

关键词：

carotenoids; superoxide; nitric oxide; anti-oxidation;

D O I：

10.1016/S0304-3835(99)00351-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Excessive and prolonged generation of superoxide (O-2(-)) and nitric oxide (NO) from inflammatory leukocytes is associated with several Lifestyle-related diseases, including cancer. In the present study, we screened 19 natural carotenoids for their modifying effects on O-2(-) and NO generation from differentiated human promyelocytic HL-60 cells and mouse macrophage RAW 264.7 cells, respectively. Of the carotenoids tested, halocynthiaxanthin, isolated from oysters, showed the highest suppressive effect on the generation of both free radicals. The inhibitory potencies of certain carotenoids on radical generation markedly exceeded that of beta-carotene. In addition, some important structural moieties regulating radical generation suppression are discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：115 / 123

页数：9

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