Targeted drug delivery for brain cancer treatment

被引：67

作者：

Gutman, RL ^{[1
]}

Peacock, G ^{[1
]}

Lu, DR ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2000年 / 65卷 / 1-2期

关键词：

brain cancer; drug therapy; biodegradable; sustained release; LDL; low density lipoprotein;

D O I：

10.1016/S0168-3659(99)00229-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The blood brain barrier (BBB) and the systemic toxicity of conventional chemotherapy present obstacles to the success of future blood-borne drug therapies of brain tumors. The work with polymer-encapsulated cancer drugs suggests an alternative and more focused treatment approach. Our experimental strategy integrates direct intracerebral drug delivery, sustained drug release from liposomes or polymer implants, and increased targeting of the drug either by chemically modifying the drug or by using tumor-specific carriers. This review will present some of the recent work on targeted drug delivery for brain cancer treatment. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：31 / 41

页数：11

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