Phosphoinositide-generated messengers in cardiac signal transduction

被引：20

作者：

vanHeugten, HAA ^{[1
]}

EskildsenHelmond, YEG ^{[1
]}

deJonge, HW ^{[1
]}

Bezstarosti, K ^{[1
]}

Lamers, JMJ ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM, FAC MED & HLTH SCI,DEPT BIOCHEM, CARDIOVASC RES INST,COEUR, 3000 DR ROTTERDAM, NETHERLANDS

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1996年 / 157卷 / 1-2期

关键词：

phosphatidylinositol cycle; cardiomyocytes; receptors; G-proteins; phospholipase C; (patho)physiological implications;

D O I：

10.1007/BF00227875

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A multitude of agonists like e.g. endothelin-l, angiotensin-II, serotonin, thrombin, histamine and vasopressin as well as a, adrenergic and muscarinic stimulation lead to stimulation of the phosphoinositide cycle in the heart. Besides this seven membrane spanning-domain receptor-coupled stimulation of the key enzyme of the phosphoinositide cycle, phospholipase C-P, another class of hormones, growth factors, also couple to the phosphoinositide cycle, now through receptors with intrinsic tyrosine kinase activity that can phosphorylate and stimulate the phospholipase C-gamma isozyme. In this review we summarize the multitude of receptor (sub)types, G-protein-subunit- and phospholipase C-isozymes that are present in the heart. Furthermore, generation of second messengers and cellular responses are described together with the (patho)physiological implications for the heart of phosphoinositide cycle activation and second messenger accumulation.

引用

页码：5 / 14

页数：10

共 88 条

[1] ANGIOTENSIN-INDUCED DESENSITIZATION OF THE PHOSPHOINOSITIDE PATHWAY IN CARDIAC-CELLS OCCURS AT THE LEVEL OF THE RECEPTOR [J].