Crystal and molecular structure of a histo-blood group antigen involved in cell adhesion: The Lewis x trisaccharide

被引：81

作者：

Perez, S

MouhousRiou, N

Nifantev, NE

Tsvetkov, YE

Bachet, B

Imberty, A

机构：

[1] ND ZELINSKII INST ORGAN CHEM, MOSCOW 117913, RUSSIA

[2] DEPT MACROMOL BIOL, LAB MINERAL CRISTALLOG, F-75252 PARIS 05, FRANCE

[3] CNRS, ORGAN SYNTH LAB, F-44072 NANTES 03, FRANCE

来源：

GLYCOBIOLOGY | 1996年 / 6卷 / 05期

关键词：

histo-blood group; cell adhesion; carbohydrate-carbohydrate interactions; Lewis x; trisaccharide;

D O I：

10.1093/glycob/6.5.537

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This work describes the first crystal structure ever reported of a histo-blood group carbohydrate antigen: Le(x), This study provides a detailed description of the conformation of two crystallographic independent molecules in a highly hydrated environment along with their hydrogen bonding properties and packing features, Some interactions observed between adjacent trisaccharides can provide the basis for involvement of Le(x)-Le(x) interactions in cell-cell adhesion.

引用

页码：537 / 542

页数：6

共 33 条

[1] PREPARATION OF DISACCHARIDES HAVING A BETA-D-MANNOPYRANOSYL GROUP FROM N-PHTHALOYLLACTOSAMINE DERIVATIVES BY DOUBLE OR TRIPLE SN2 SUBSTITUTION [J].