Synthesis and antibacterial activity of 4- and 8-methoxy trinems

被引：25

作者：

Andreotti, D

Rossi, T

Gaviraghi, G

Donati, D

Marchioro, C

DiModugno, E

Perboni, A

机构：

[1] Glaxo Research Laboratories, 37138 Verona

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/0960-894X(96)00056-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of all the isomers of 8-methoxy-(9S,10S,12R)-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo-[7.2.0.0(3,8])-undec-2-ene-carboxylates 2 and 4-methoxy-(9R,10S,12R)-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo-[7.2.0.0(3.8)]-undec-2-ene-carboxylates 3 is described. The biological data obtained indicated that the (4S,8S)-4-methoxy derivative (3b) is the best compound in terms of microbiological activity, breadth of spectrum of action and stability to hydrolytic enzymes, namely beta-lactamases.

引用

页码：491 / 496

页数：6

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