Transcription control: Repressed repeats express themselves

被引：17

作者：

Wolffe, AP

机构：

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(06)00408-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multi copy transgenes are poorly expressed in plants, Drosophila and mammals; this repression is relieved by reducing copy number, leading to chromatin remodeling and transcriptional activation, Host defense mechanisms monitor repeated sequences in the genome, modulating their chromatin packaging and functional capabilities.

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页码：R796 / R798

页数：3

相关论文

共 10 条

[1]

ASHE HL, 1997, IN PRESS GENES DEV

[2] EPIGENETIC REPEAT-INDUCED GENE SILENCING (RIGS) IN ARABIDOPSIS [J].

ASSAAD, FF ;

TUCKER, KL ;

SIGNER, ER .

PLANT MOLECULAR BIOLOGY, 1993, 22 (06) :1067-1085

[3] THE DROSOPHILA-ZESTE PROTEIN BINDS COOPERATIVELY TO SITES IN MANY GENE REGULATORY REGIONS - IMPLICATIONS FOR TRANSVECTION AND GENE-REGULATION [J].

BENSON, M ;

PIRROTTA, V .

EMBO JOURNAL, 1988, 7 (12) :3907-3915

[4] CYTOSINE METHYLATION - THE PROS AND CONS OF DNA METHYLATION [J].

BESTOR, TH ;

COXON, A .

CURRENT BIOLOGY, 1993, 3 (06) :384-386

[5] EXPANSIONS OF TRANSGENE REPEATS CAUSE HETEROCHROMATIN FORMATION AND GENE SILENCING IN DROSOPHILA [J].

DORER, DR ;

HENIKOFF, S .

CELL, 1994, 77 (07) :993-1002

[6]

GARRICK D, 1997, IN PRESS NAT GENET

[7] Regulation of beta-globin gene expression: Straightening out the locus [J].

Martin, DIK ;

Fiering, S ;

Groudine, M .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (04) :488-495

[8] HOW AND WHY DO PLANTS INACTIVATE HOMOLOGOUS (TRANS)GENES [J].

MATZKE, MA ;

MATZKE, AJM .

PLANT PHYSIOLOGY, 1995, 107 (03) :679-685

[9] Cosuppression in Drosophila: Gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent [J].

PalBhadra, M ;

Bhadra, U ;

Birchler, JA .

CELL, 1997, 90 (03) :479-490

[10] INSULATING CHROMATIN [J].

WOLFFE, AP .

CURRENT BIOLOGY, 1994, 4 (01) :85-87