A prospective, open-label safety and efficacy study of combination treatment with melphalan, arsenic trioxide, and ascorbic acid in patients with relapsed or refractory multiple myeloma

被引:8
作者
Berenson, JR [1 ]
Swift, RA [1 ]
Ferretti, D [1 ]
Purner, MB [1 ]
机构
[1] Inst Myeloma & Bone Canc Res & Oncotherapeut, Los Angeles, CA USA
来源
CLINICAL LYMPHOMA | 2004年 / 5卷 / 02期
关键词
apoptosis; neutropenial reactive oxygen status; serum M-protein; thrombocytopenia;
D O I
10.3816/CLM.2004.n.020
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:130 / 134
页数:5
相关论文
共 21 条
[1]  
Bahlis NJ, 2002, CLIN CANCER RES, V8, P3658
[2]  
BERENSON J, 2003, 9 INT WORKSH MULT MY
[3]  
BORAD MJ, 2004, IN PRESS LEUKEMIA
[4]   Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia [J].
Cai, X ;
Shen, YL ;
Zhu, Q ;
Jia, PM ;
Yu, Y ;
Zhou, L ;
Huang, Y ;
Zhang, JW ;
Xiong, SM ;
Chen, SJ ;
Wang, ZY ;
Chen, Z ;
Chen, GQ .
LEUKEMIA, 2000, 14 (02) :262-270
[5]   Progress in haematopoietic stem cell transplantation for multiple myeloma [J].
Gahrton, G ;
Björkstrand, B .
JOURNAL OF INTERNAL MEDICINE, 2000, 248 (03) :185-201
[6]  
Gartenhaus RB, 2002, CLIN CANCER RES, V8, P566
[7]   Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells [J].
Grad, JM ;
Bahlis, NJ ;
Reis, I ;
Oshiro, MM ;
Dalton, WS ;
Boise, LH .
BLOOD, 2001, 98 (03) :805-813
[8]  
Hayashi T, 2002, MOL CANCER THER, V1, P851
[9]   Phase 2 study of arsenic trioxide in patients with relapsed or refractory multiple myeloma [J].
Hussein, MA ;
Saleh, M ;
Ravandi, F ;
Mason, J ;
Rifkin, RM ;
Ellison, R .
BRITISH JOURNAL OF HAEMATOLOGY, 2004, 125 (04) :470-476
[10]   Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway [J].
Jing, YK ;
Dai, J ;
Chalmers-Redman, RME ;
Tatton, WG ;
Waxman, S .
BLOOD, 1999, 94 (06) :2102-2111