Neurosteroids, with special reference to the effect of progesterone on myelination in peripheral nerves

被引:30
作者
Baulieu, EE [1 ]
Schumacher, M [1 ]
机构
[1] COLL FRANCE, PARIS, FRANCE
关键词
myelination; progesterone; neurosteroid; sciatic nerve; Schwann cells;
D O I
10.1177/135245859700300209
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Some steroids ore synthesized within the central and peripheral nervous system, mostly by glial cells. These ore known as neurosteroids. In the brain, neurosteroids have been shown to act directly on membrane receptors for neurotransmitters. For example, progesterone inhibits the neuronal nicotinic acetylcholine receptor, whereas its 3 alpha,5 alpha-reduced metabolite 3 alpha,5 alpha-tetrahydroprogesterone (allopregnanolane) activates the A gamma-aminobutyric acid receptor complex. Besides these effects, neurosteroids also regulate important glial functions, such as the synthesis of myelin proteins. Thus, in cultures of glial cells prepared from neonatal rot brain, progesterone increases the number of oligodendrocytes expressing the myelin basic protein (MBP) and the 2',3'-cyclic nucleotide-3'-phophodiesterose (CNPase). An important role for neurosteroids in myelin repair has been demonstrated in the rodent sciatic nerve, where progesterone and its direct Precursor pregnenolone ore synthesized by Schwann cells. After cryolesion of the mole mouse sciatic nerve, blocking the local synthesis or action of progesterone impairs remyelination of the regenerating axons, whereas administration of progesterone to the lesion site promotes the formation of new myelin sheaths.
引用
收藏
页码:105 / 112
页数:8
相关论文
共 51 条
[1]  
AKWA Y, 1993, CR ACAD SCI III-VIE, V316, P410
[2]   ASTROCYTES AND NEUROSTEROIDS - METABOLISM OF PREGNENOLONE AND DEHYDROEPIANDROSTERONE - REGULATION BY CELL-DENSITY [J].
AKWA, Y ;
SANANES, N ;
GOUEZOU, M ;
ROBEL, P ;
BAULIEU, EE ;
LEGOASCOGNE, C .
JOURNAL OF CELL BIOLOGY, 1993, 121 (01) :135-143
[3]  
Baulieu E. E., 1981, Steroid Hormone Regulation of the Brain, P3
[4]   NEUROSTEROIDS - A NEW FUNCTION IN THE BRAIN [J].
BAULIEU, EE .
BIOLOGY OF THE CELL, 1991, 71 (1-2) :3-10
[5]  
Baulieu EE, 1995, CIBA F SYMP, V191, P24
[6]   DEHYDROEPIANDROSTERONE AND ITS SULFATED DERIVATIVE REDUCE NEURONAL DEATH AND ENHANCE ASTROCYTIC DIFFERENTIATION IN BRAIN-CELL CULTURES [J].
BOLOGA, L ;
SHARMA, J ;
ROBERTS, E .
JOURNAL OF NEUROSCIENCE RESEARCH, 1987, 17 (03) :225-234
[7]   STUDIES ON CULTURED RAT SCHWANN-CELLS .1. ESTABLISHMENT OF PURIFIED POPULATIONS FROM CULTURES OF PERIPHERAL-NERVE [J].
BROCKES, JP ;
FIELDS, KL ;
RAFF, MC .
BRAIN RESEARCH, 1979, 165 (01) :105-118
[8]  
CELOTTI F, 1992, FRONT NEUROENDOCRIN, V13, P163
[9]  
CHADWICK D, 1990, CIBA FDN S, V153
[10]   PREGNENOLONE AND ITS SULFATE ESTER IN THE RAT-BRAIN [J].
CORPECHOT, C ;
SYNGUELAKIS, M ;
TALHA, S ;
AXELSON, M ;
SJOVALL, J ;
VIHKO, R ;
BAULIEU, EE ;
ROBEL, P .
BRAIN RESEARCH, 1983, 270 (01) :119-125