Creutzfeldt-Jakob disease cluster in an Australian rural city

被引：14

作者：

Collins, S

Boyd, A

Fletcher, A

Kaldor, J

Hill, A

Farish, S

McLean, C

Ansari, Z

Smith, M

Masters, CL

机构：

[1] Univ Melbourne, Australian Natl Creutzfeldt Jakob Dis Registry, Dept Pathol, Parkville, Vic 3010, Australia

[2] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res Unit, Sydney, NSW, Australia

[3] Univ Melbourne, Sch Populat Hlth, Epidemiol & Biostat Unit, Melbourne, Vic, Australia

[4] Dept Human Serv, Publ Hlth Div, Hlth Outcomes Sect, Melbourne, Vic, Australia

[5] Royal Melbourne Hosp, Melbourne Hlth Shared Pathol Serv, Mol Biol Lab, Parkville, Vic 3050, Australia

来源：

ANNALS OF NEUROLOGY | 2002年 / 52卷 / 01期

关键词：

D O I：

10.1002/ana.10224

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.

引用

页码：115 / 118

页数：4

共 17 条

[1] How is Creutzfeldt-Jakob disease acquired? [J].