Synthesis of 2,4-dihydroxyquinazolines using carbon dioxide in the presence of DBU under mild conditions

被引：92

作者：

Mizuno, T ^{[1
]}

Okamoto, N ^{[1
]}

Ito, T ^{[1
]}

Miyata, T ^{[1
]}

机构：

[1] Osaka Municipal Tech Res Inst, Joto Ku, Osaka 5368553, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 07期

关键词：

carbonylation; cyclisation; quinazolines; quinazolinones;

D O I：

10.1016/S0040-4039(99)02231-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical fixation of carbon dioxide was performed under mild conditions. Carbon dioxide (1 atm) easily reacted with 2-aminobenzonitriles at 20 degrees C, assisted by DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) to give 2,4-dihydroxyquinazolines in excellent yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1051 / 1053

页数：3

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