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Observations and suggestions on antidementia drug development
被引：55
作者：
Leber, P
机构：
关键词：
drug product development;
clinical trials;
re-randomized design;
randomized start design;
D O I：
10.1097/00002093-199601031-00009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recent advances in the theoretical neurosciences have suggested a number of novel strategies that might be applied to prevent and/or retard the progression of Alzheimer disease. Whether or not these interventions will succeed cannot be determined on theoretical grounds, however; the value of each new stratagem must be evaluated in patients with Alzheimer disease. How best to conduct clinical studies of disease-modifying treatments remains a controversial subject. The author reviews and compares two clinical trial designs that may prove useful in assessing whether or not a putative treatment actually modifies the course of dementia.
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页码：31 / 35
页数：5
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