Negative control of flagellum synthesis in Pseudomonas aeruginosa is modulated by the alternative sigma factor AlgT (AlgU)

被引：110

作者：

Garrett, ES ^{[1
]}

Perlegas, D ^{[1
]}

Wozniak, DJ ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Dept Microbiol & Immunol, Winston Salem, NC 27157 USA

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 23期

关键词：

D O I：

10.1128/JB.181.23.7401-7404.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Many respiratory isolates of Pseudomonas aeruginosa from cystic fibrosis patients are mucoid (alginate producing) yet lack flagella. It was hypothesized that an alginate regulator inhibits flagellar gene expression. Mutations in algB, algR, and algT resulted in nonmucoid derivatives, yet algT mutants expressed flagella. AlgT-dependent control of flagellum synthesis occurred through inhibition of fliC but not rpoN transcription.

引用

页码：7401 / 7404

页数：4

共 23 条

[1] The Pseudomonas aeruginosa flagellar cap protein, FliD, is responsible for mucin adhesion
Arora, SK
Ritchings, BW
Almira, EC
Lory, S
Ramphal, R
[J]. INFECTION AND IMMUNITY, 1998, 66 (03) : 1000 - 1007
[2] Transcriptional activator, FleQ, regulates mucin adhesion and flagellar gene expression in Pseudomonas aeruginosa in a cascade manner
Arora, SK
Ritchings, BW
Almira, EC
Lory, S
Ramphal, R
[J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (17) : 5574 - 5581
[3] Identification and characterization of AlgZ, an AlgT-dependent DNA-binding protein required for Pseudomonas aeruginosa algD transcription
Baynham, PJ
Wozniak, DJ
[J]. MOLECULAR MICROBIOLOGY, 1996, 22 (01) : 97 - 108
[4] MUCOID-TO-NONMUCOID CONVERSION IN ALGINATE-PRODUCING PSEUDOMONAS-AERUGINOSA OFTEN RESULTS FROM SPONTANEOUS MUTATIONS IN ALGT, ENCODING A PUTATIVE ALTERNATE SIGMA-FACTOR, AND SHOWS EVIDENCE FOR AUTOREGULATION
DEVRIES, CA
OHMAN, DE
[J]. JOURNAL OF BACTERIOLOGY, 1994, 176 (21) : 6677 - 6687
[5] AMINO-TERMINAL AMINO-ACIDS MODULATE SIGMA-FACTOR DNA-BINDING ACTIVITY
DOMBROSKI, AJ
WALTER, WA
GROSS, CA
[J]. GENES & DEVELOPMENT, 1993, 7 (12A) : 2446 - 2455
[6] Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection
Feldman, M
Bryan, R
Rajan, S
Scheffler, L
Brunnert, S
Tang, H
Prince, A
[J]. INFECTION AND IMMUNITY, 1998, 66 (01) : 43 - 51
[7] CLONING OF GENES FROM MUCOID PSEUDOMONAS-AERUGINOSA WHICH CONTROL SPONTANEOUS CONVERSION TO THE ALGINATE PRODUCTION PHENOTYPE
FLYNN, JL
OHMAN, DE
[J]. JOURNAL OF BACTERIOLOGY, 1988, 170 (04) : 1452 - 1460
[8] Microbial pathogenesis in cystic fibrosis: Mucoid Pseudomonas aeruginosa and Burkholderia cepacia
Govan, JRW
Deretic, V
[J]. MICROBIOLOGICAL REVIEWS, 1996, 60 (03) : 539 - +
[9] A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences:: application for isolation of unmarked Pseudomonas aeruginosa mutants
Hoang, TT
Karkhoff-Schweizer, RR
Kutchma, AJ
Schweizer, HP
[J]. GENE, 1998, 212 (01) : 77 - 86
[10] FORMATION OF PILIN IN PSEUDOMONAS-AERUGINOSA REQUIRES THE ALTERNATIVE SIGMA-FACTOR (RPON) OF RNA-POLYMERASE
ISHIMOTO, KS
LORY, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) : 1954 - 1957

← 1 2 3 →