Anti-HBs levels after hepatitis B immunisation depend on test reagents: routinely determined 10 and 100 IU/l seroprotection levels unreliable

被引：25

作者：

Heijtink, RA ^{[1
]}

Schneeberger, PM

Postma, B

Crombach, W

机构：

[1] Erasmus Univ, Dept Virol, NL-3000 DR Rotterdam, Netherlands

[2] St Maartensgasthuis, Venlo, Netherlands

[3] St Joseph Hosp, Veldhoven, Netherlands

[4] Boschmedicentrum, Shertogenbosch, Netherlands

来源：

VACCINE | 2002年 / 20卷 / 23-24期

关键词：

anti-HBs assay; antigenic subtype; quantitation;

D O I：

10.1016/S0264-410X(02)00233-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

In a large series of post-vaccination samples we compared the result of three commercially available anti-HBs assays (AxSYM, Architect and Access) on the quantitation of anti-HBs after immunisation with Engerix-B (HBsAg/ad) and GenHevacB (HBsAg/ay) vaccine. Two of the assays (AxSYM, Architect: Abbott Laboratories) gave related but not identical results with HBsAg from different sources. The result of the third assay (Access, Beckman Coulter) was related to that of AxSYM and Architect only for GenHevacB anti-HBs but differed for Engerix-B anti-HBs (P < 0.001). This vaccine dependent discrepancy was also observed with the Vidas anti-HBs assay (BioMerieux). An external WHO reference panel could harmonise geometric mean anti-HBs levels from the four assays for GenHevacB but not for Engerix-B vaccination sera. We conclude that the individually determined anti-HBs level (IU/l) strongly depend on the test reagents and the vaccine under study. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2899 / 2905

页数：7

共 10 条

[1]

Immunogenicity of hepatitis B vaccines - Implications for persons at occupational risk of hepatitis B virus infection [J].

Averhoff, F ;

Mahoney, F ;

Coleman, P ;

Schatz, G ;

Hurwitz, E ;

Margolis, H .

AMERICAN JOURNAL OF PREVENTIVE MEDICINE, 1998, 15 (01) :1-8

[2]

LONG-TERM IMMUNOGENICITY AND EFFICACY OF HEPATITIS-B VACCINE IN HOMOSEXUAL MEN [J].

HADLER, SC ;

FRANCIS, DP ;

MAYNARD, JE ;

THOMPSON, SE ;

JUDSON, FN ;

ECHENBERG, DF ;

OSTROW, DG ;

OMALLEY, PM ;

PENLEY, KA ;

ALTMAN, NL ;

BRAFF, E ;

SHIPMAN, GF ;

COLEMAN, PJ ;

MANDEL, EJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (04) :209-214

[3]

HADLER SC, 1991, VIRAL HEPATITIS AND LIVER DISEASE, P766

[4]

Hepatitis B surface antigen (HBsAg) derived from yeast cells (Hansenula polymorpha) used to establish an influence of antigenic subtype (adw2, adr, ayw3) in measuring the immune response after vaccination [J].

Heijtink, RA ;

van Bergen, P ;

Melber, K ;

Janowicz, ZA ;

Osterhaus, ADME .

VACCINE, 2002, 20 (17-18) :2191-2196

[5]

Anti-HBs characteristics after hepatitis B immunisation with plasma-derived and recombinant DNA-derived vaccines [J].

Heijtink, RA ;

van Bergen, P ;

Paulij, WP ;

de Man, RA ;

Osterhaus, ADME .

VACCINE, 2000, 18 (15) :1531-1538

[6]

PERSISTENCE OF SPECIFIC ANTIBODIES AFTER HEPATITIS-B VACCINATION [J].

JILG, W ;

SCHMIDT, M ;

DEINHARDT, F .

JOURNAL OF HEPATOLOGY, 1988, 6 (02) :201-207

[7]

PETRE J, 1987, POSTGRAD MED J, V63, P73

[8]

Antibody-response to three recombinant hepatitis B vaccines: comparative evaluation of multicenter travel-clinic based experience [J].

Rendi-Wagner, P ;

Kundi, M ;

Stemberger, H ;

Wiedermann, G ;

Holzmann, H ;

Hofer, M ;

Wiesinger, K ;

Kollaritsch, H .

VACCINE, 2001, 19 (15-16) :2055-2060

[9]

HEPATITIS-B VACCINE RESPONSIVENESS IN CONNECTICUT PUBLIC SAFETY PERSONNEL [J].

ROOME, AJ ;

WALSH, SJ ;

CARTTER, ML ;

HADLER, JL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (24) :2931-2934

[10]

Vaccine induced immunologic memory for hepatitis B surface antigen: Implications for policy on booster vaccination [J].

West, DJ ;

Calandra, GB .

VACCINE, 1996, 14 (11) :1019-1027

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