Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

被引：31

作者：

Choi, KS

Grab, DJ

Dumler, JS

机构：

[1] Johns Hopkins Univ, Div Med Microbiol, Dept Pathol, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Div Infect Dis, Dept Pediat, Sch Med, Baltimore, MD 21205 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 06期

关键词：

D O I：

10.1128/IAI.72.6.3680-3683.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for greater than or equal to18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

引用

收藏

页码：3680 / 3683

页数：4

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