A polymer-enlarged homogeneously soluble oxazaborolidine catalyst for the asymmetric reduction of ketones by borane

被引:64
作者
Felder, M [1 ]
Giffels, G [1 ]
Wandrey, C [1 ]
机构
[1] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, INST BIOTECHNOL, D-52425 JULICH, GERMANY
关键词
D O I
10.1016/S0957-4166(97)00192-4
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A polymer-enlarged homogeneously soluble oxazaborolidine catalyst has been prepared and used in the enantioselective borane reduction of ketones. The catalyst is derived from (2S,4R)-alpha,alpha-diphenyl-2-[(4-allyloxy)-N-benzyloxycarbonyl]pyrrolidinemethanol 3 and a methyl hydrosiloxane-dimethylsiloxane copolymer 4 (15% functionalized). Enantioselective reduction of prochiral ketones to the corresponding chiral alcohols proceeds with enantiomeric excesses up to 98%. The catalyst can be retained by a nanofiltration membrane and thus could be recovered after reaction or used in a continuously operated membrane reactor. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:1975 / 1977
页数:3
相关论文
共 27 条