Toward an Effective Targeted Chemotherapy for Multiple Myeloma

被引：10

作者：

Poison, Andrew G. ^{[1
]}

Sliwkowski, Mark X. ^{[1
]}

机构：

[1] Genentech Inc, Res Oncol, San Francisco, CA 94080 USA

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 12期

关键词：

CANCER-THERAPY; CELLS;

D O I：

10.1158/1078-0432.CCR-09-0572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antibody-drug conjugates (ADCs), cytotoxic drugs chemically linked to antibodies, provide a means to increase the effectiveness of chemotherapy by targeting the drug to neoplastic cells. Anti-CD138 ADCs show promising preclinical efficacy for the treatment of multiple myeloma; however, the safety aspects of targeting CD138 have yet to be explored.

引用

页码：3906 / 3907

页数：2

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