Human papillomavirus type 32 does not display in vitro transforming properties

被引：16

作者：

Caldeira, S

Dong, W

Tomakidi, P

Paradiso, A

Tommasino, M ^{[1
]}

机构：

[1] Deutsch Krebsforschungszentrum, INF 242, D-69120 Heidelberg, Germany

[2] Univ Heidelberg, Sch Dent, Dept Orthodont & Dentofacial Orthoped, Heidelberg, Germany

[3] Ist Oncol, Bari, Italy

来源：

VIROLOGY | 2002年 / 301卷 / 01期

关键词：

focal epithelial hyperplasia; HPV32; E6 and E7; cell cycle and apoptosis;

D O I：

10.1006/viro.2002.1623

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human papillomavirus type 32 (HPV32) is one of the etiological agents of a benign oral condition, focal epithelial hyperplasia. However, the previously characterized properties of its E7 oncoprotein suggest a possible malignant nature for this virus. In this study we characterized the properties of HPV32 E6 and E7. Our data show that HPV32 E7, despite its high affinity for pRb, does not promote degradation of the cellular protein. In addition, HPV32 E6 does not prevent p53-mediated apoptosis and/or cell cycle arrest. Moreover, coexpression of HPV32 E6 and E7 in primary human fibroblasts or keratinocytes does not alter their proliferative state. Together, these data provide evidence of the benign nature of HPV32. (C) 2002 Elsevier Science (USA).

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页码：157 / 164

页数：8

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