Bioinspired bone therapies using naringin: applications and advances

被引：91

作者：

Lavrador, Pedro ^{[1
]}

Gaspar, Vitor M. ^{[1
]}

Mano, Joao F. ^{[1
]}

机构：

[1] Univ Aveiro, Aveiro Inst Mat, CICECO, Dept Chem, Campus Univ Santiago, P-3810193 Aveiro, Portugal

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 06期

基金：

欧洲研究理事会;

关键词：

NF-KAPPA-B; CONTROLLED-RELEASE STRATEGIES; NATURAL-PRODUCTS; RAT MODEL; OSTEOPOROSIS; MECHANISMS; DIFFERENTIATION; ANGIOGENESIS; CARTILAGE; EXPRESSION;

D O I：

10.1016/j.drudis.2018.05.012

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.

引用

收藏

页码：1293 / 1304

页数：12

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